Let the fake face be in front of you, the real face will be hidden

- The Science of Reverse Aging, which reverses the biological decline of aging from youth.

- A look this way-Harshal Pushkarna

- Reverse Aging = Rejuvenation of the body that has already entered the forest! Although the calendar shows an age figure of fifty plus, the body assumes the appearance of being in the forties.

Before embarking on this interesting discussion, patiently read the short and at first glance dull news item that sparked the discussion. On December 7th, scientists at the Hong Kong University of Science and Technology announced that they had identified the type of 'aging' muscle stem cells responsible for human aging. After this research, the science of reverse aging has taken a step forward. I'm done with the news!

Now learn the biology behind the news, which is neither dull nor dry. Rather, the brain is overwhelmed by thoughts. The extent to which the 'company fitted' software program of nature's anatomical biological machine can be changed through genetic engineering called reverse engineering is proving to be the driving force of the ideological frenzy. Believed that the science of reversing the aging/ageing decline from youth to maturity is still in the cradle of imagination. However, the imagination is not completely unsophisticated; It is built on a solid foundation of science. Let us understand the brick-cut of masonry in a little detail.

Human body is made up of 37,200 billion cells. The variety of cells is not less than 200. A cell of that variety has to perform some or all biological functions in the body. As such, the job of red blood cells is to pick up oxygen that enters the lungs and transport it throughout the body through the blood vessels. Neurons carry out command-like electrical signals related to movements originating in the brain to the hands and feet, while the eye-like lens has the task of distinguishing visual rays. Our heart beats by an invisible whip at an average of 72 times per minute, the cells are pacemaker cells! In this way, if 200 types of cells keep doing their work 24/7 and only then the human body can be healthy.

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When a baby is born, its anatomical covering is made up of a tissue of 26 billion cells. As the days pass, new cells are formed as the cells divide and eventually the rash spreads. It means that the body grows. The creation of new cells, the elimination of unnecessary cells and the creation of new cells to take their vacated place is an unstoppable biological process. As the child progresses into adulthood, the number of new cells outnumbers the cells that die, but after forty, the balance of cells reverses. This means that the score of dying cells is higher than the number of newly formed cells, so the body begins to change gradually. for example-

; The collagen and elastin fibers (fibers) in the layer called the dermis, which lies beneath the skin, lose their strength and become brittle. While the complex network of these two fibers is erect during youth, the skin also remains smooth and even with their support. As we age, the collagen and elastin columns begin to sag, causing the skin to 'sag'. Wrinkles form all over the body including the face.

; We have got a warm blanket of fat under the skin to protect us from the cold. As we age, the blanket becomes thinner as fat cells are wasted. The result? Wear an extra sweater to ward off the hoo...hoo...hoo... in winter!

; After the blood is purified in a natural filter called the kidney, the residual impurities are collected in the bladder along with urine. The muscle cells that increase or decrease the size of the bladder according to the amount of urine produced degenerate with age. The elasticity of the bladder is not what it used to be, so it cannot hold more urine. The result? Every little while you have to get up for a small recess.

Aging in English and ageing in Gujarati can give many other examples, but at the end of each one the question that arises in the mind is the same: What biological factor drives a person from youth to old age?

Years ago, a gerontologist named Zoris Medvedov from Russia asked the above question. Zoris Medvedoff was an expert in a special branch of the study of aging called gerontology. After spending many years of his life in the intensive study of physiology, he concluded that a total of 300 biological factors are responsible for human aging. The figure of three hundred may seem excessive, but no gerontologist in the world has been able to tell the plus-minus difference in the last forty years. The figure represented by Zoris Medvedev is still eternal.

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Note that the figure of 300 quoted above is for the causative factors of aging; Not the reasons. There is a difference in both. Factors regarding aging that apply to the individual according to his body, diet, environment, habits etc., while the invisible rod of reason drives all human beings towards aging equally. Today, modern science is well aware that the most important cause of aging is the depletion or loss of muscle stem cells/sageb type cells.

When you do physical activities like exercising, running, walking, lifting weights, writing, working on the computer, cooking, etc., that wears down those muscles. In other words, some muscle cells are destroyed. If this type of waste is done on a daily basis, then in a few moments the muscles will become completely wasted and it will be difficult for the human being to do normal movements. Fortunately for us, new muscle cells keep coming in to counter the outflow of worn-out muscle cells - and that's the job Muscle Stem Cells/MuSc has got. The DNA in such cells (deoxyribonucleic acid) divides and makes an exact copy of itself, i.e., based on that copy, completely new muscle cells are formed and take their place at the correct address on a 'vacant space' basis. The whole process is very complex, but here we have tried to explain it briefly and in as simple terms as possible. Read on with concentration-

A 'replacement' signal comes from worn-out muscle cells, meaning that the compact and tight tangle of DNA in muscle stem cells automatically loosens up a bit. After the sloth dies, it makes an exact copy of itself and reverts to a turtle-like hybrid state, becoming a duplicate version. Maintaining this type of resilience is essential—and a special type of protein does the job of maintaining it. As we age, the production of that protein slows down or stops. As a result, the DNA in muscle stem cells is not as elastic as before due to its absence. A tangle cannot assume a compact state. Rather, it loosens up. This has a direct effect on the production of new muscle cells. DNA does not break down like it used to. No division, no question of making new muscle cells. The next course of events is very natural. When the muscle cells that are worn out on a daily basis are not replenished with new cells, the body begins to slowly atrophy. Another name for this condition is aging!

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Having fully understood (and re-reading if necessary) the last two paragraphs above, shall we proceed? Let's refresh the news we gave before editing the article. Scientists in Hong Kong have identified senescent muscle stem cells/MuSc types of cells responsible for human aging. The explanation of why this should be considered a huge achievement begins now.

As mentioned earlier, the DNA strand in aged muscle stem cells has lost its original elasticity due to the lack of specific proteins. Such senior citizen cells cannot give birth to new cells. But what if the protein that gives aging cells the resilience of their DNA is given a medical treatment called gene therapy? Can those old cells start producing new muscle cells again?

why not? Of course, start doing.

If the production of new muscle cells begins to ramp up, will all of the wasted body lose all the muscle again?

why not? Be sure!

Then, on that account, the mature body begins to retreat towards youth or not?

The answer to this question is again the same: why not?

This is called reverse ageing, in which the aging body re-enters youth. Although the calendar shows the age as fifty plus, the body assumes the appearance of being in the forties. Using a line from a song from the film 'Izzat' by cinestar Dharmendra, metaphorically speaking, the fake (istritite) face is in front of you, the real (wrinkled) face is hidden.

All this patte ki roti ban jaye aur pani ka ghee ban jaye seems like a pink dream, then know that the dream is not just a daydream. There have been hundreds of instances in the world of science where what appears to be science fiction today has turned into science fact tomorrow. It is not impossible to reactivate aged muscle stem cells with gene therapy to get the biological factory of muscle cells humming, so it is not impossible to reverse aging or slow down the aging process. The only question is time. An idea that seems silly today will not be said if it turns out to be an arrow and fishes the target even in the distant future. If that happens then the folk song 'Jobniya aaj ai ne kalya jashe... Jobninah kalya jatun re'she' sung by Hemu Gadhvi would not seem to fit in that era of reverse aging. Because after going there is nowhere to go!